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Publications

1. Szablowski JO*, Molecular Engineering Technology for Studying and Treating the Brain, Chemical Engineering Progress (2024)

2. Huang Z, Mitrofan A, Nouraein S, Horak C, Seo JP, Harb M, Jin R, Szablowski JO*. Engineering Regionally-Activated Drugs for Neuroscience. bioRxiv. 2023:2023-10. (2023)

3. Seo JP, Trippett JS, Huang Z, Wang R, Lee S, Szablowski JO*, Acoustically-Targeted Measurement of Transgene Expression in the Brain,  bioRxiv 2023.05.23.541868; doi: https://doi.org/10.1101/2023.05.23.541868 ​(2023)

4. Lee, S., Nouraein, S., Kwon, J. J., Huang, Z., Wojick, J. A., Xia, B., Corder G., Szablowski, J. O., Engineered serum markers for non-invasive monitoring of gene expression in the brain. https://doi.org/10.1038/s41587-023-02087-x, Nature Biotechnology (2024).

 

5. Nouraein S, Lee S, Saenz VA, Del Mundo HC, Yiu J, Szablowski JO*, Acoustically Targeted Noninvasive Gene Therapy in Large Brain Regions, in press, Gene Therapy  (2023)

6. Chen, M., Kim, B., Ruocco, M.1, Fleury, S., Deng, S., Nouraein, S. Lee, S., Butler, S., Szablowski, J.O., Suh, J., Veiseh, O. Immune profiling of adeno-associated virus response identifies B cell-specific targets that enable vector re-administration in mice. Gene Ther 30, 429–442 (2023).

7. Xia B*, Sebesta C*, Lee S*, Nair V, Zhao X, Coffler S, Robinson JT#, Szablowski JO#, Biohybrid approaches to interface with the nervous system: the best of both worlds, Current Opinion in Biotechnology, 72 (86-94), (2021)

(# corresponding)

8. Li H, Heath JE, Trippett JS, Shapiro MG#, Szablowski JO#, Engineering viral vectors for acoustically targeted gene delivery. bioRxiv 2021.07.26.453904, in press, Nature Communications (2024)

(#corresponding)

9. Szablowski JO#, Harb M, Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation, J Vis Exp . 2020 Dec 22;(166). doi: 10.3791/61352. (2020)

(# corresponding)

10. Szablowski JO*, Bar-Zion A*, Shapiro MG, Achieving spatial and molecular specificity with ultrasound-targeted biomolecular therapeutics, Accounts of chemical research 52.9 (2019): 2427-2434.

                               * co-first

11. Szablowski JO, Lue B, Lee-Gosselin A, Malounda A, Shapiro MG, Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits, Nature Biomedical Engineering, (2), 475–484 (2018);

[Highlighted in F1000 Prime]

12. Maresca, D, Lakshmanan A, Abedi M, Bar-Zion A, Farhadi A, Lu GJ, Szablowski JO, Wu D, Yoo S, and Shapiro MG, Biomolecular Ultrasound and Sonogenetics. Annual review of chemical and biomolecular engineering, 9:229-252 (2018)

13. Lu, G. J., Farhadi, A., Szablowski, J. O., Lee-Gosselin, A., Barnes, S. R., Lakshmanan, A., ... & Shapiro, M. G. Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures. Nature Materials 17, 456–463 (2018)

14. Piraner DI, Farhadi A, Davis HC, Wu D, Maresca D, Szablowski JO, Shapiro MG, Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function, Biochemistry 56 (39), 5202-5209 (2018)

15. Mysore VS, Szablowski JO, Dervan PB, Frost PJ, A DNA-binding molecule targeting the adaptive hypoxic response in multiple myeloma has potent in vivo and in vitro anti-tumor effects, Molecular Cancer Research (2016), Mol Cancer Res Published OnlineFirst January 22, 2016 
Featured in highlights: http://mcr.aacrjournals.org/content/14/3/239.full.pdf+html 

16. Szablowski, JO.; Raskatov JA., Dervan, PB. "An HRE-binding Py-Im polyamide attenuates tumor growth and inhibits angiogenesis in vivo."; Molecular Cancer Therapeutics (2015), Mol Cancer Ther molcanther.0719.2015; Published OnlineFirst December 30, 2015
Featured in highlights: http://mct.aacrjournals.org/content/15/4/531.full.pdf+html 

17. Raskatov JA.; Szablowski, JO.; Dervan, PB.; "Tumor Xenograft Uptake of a Py Im Polyamide Varies as a Function of Cell Line Grafted: a C-14 Study", Journal of Medicinal Chemistry 57 (20), 8471-8476 (2014)

18. Yang, F; Nickols, N; Li, Benjamin; Szablowski, JO; Hamilton, S; Meier, J; Wang, C; Dervan, PB, Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit, Journal of Medicinal Chemistry 56 (18), 7449-7457 (2013)

19. Nickols NG*,Szablowski JO*, Hargrove AE, Li BC, Raskatov JA, Activity of a Py-Im Polyamide Targeted to the Estrogen Response Element, Molecular Cancer Therapeutics, 12:675–84 (2013)

selected as a 'American Association for Cancer Research (AACR) hot topic 2013'.

* co-first

20. Cristina Vilanova, Ángeles Hueso, Carles Palanca, Guillem Marco,Miguel Pitarch, Eduardo Otero, Juny Crespo, Jerzy Szablowski, Sara Rivera,Laura Domínguez-Escribà, Emilio Navarro, Arnau Montagud, Pedro Fernández de Córdoba, Asier González, Joaquín Ariño,Andrés Moya, Javier Urchueguía & Manuel Porcar, "Aequorin-expressing yeast emits light under electric control" , J Biotechnol. 152(3):93-5. (2011)

21. Shapiro MG*, Westmeyer GG*, Romero P, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, & Jasanoff AP, Directed evolution of an MRI contrast agent for noninvasive imaging of dopamine. Nature Biotechnology 28, 264–270 (2010)

* co-first

22. Shapiro MG, Szablowski JO, Langer R, Jasanoff AP, Protein nanoparticles engineered to sense kinase activity in MRI, Journal of the American Chemical Society 2009 131 (7), 2484-2486

Patents

  1. Szablowski JO, Huang Z, Site Specific Brain Therapeutics, Rice Tech ID 2023-066-PZ

  2. Szablowski JO, Seo JP, "Noninvasive Site-Specific Measurement of Transgene Expression in the Brain", Rice Tech ID: 2023-067

  3. Szablowski JO, Lee S, Noninvasive monitoring of gene expression in the brain using synthetic serum markers, Rice Tech ID 2022-069, 05/30/2022

  4. Szablowski JO, Li H, Heath JE, Shapiro MG, Viral Vectors Engineered for Enhanced Ultrasound-Mediated Delivery to the Brain, Serial Number: 63/225,006, Filed: 7/23/2021, CIT File Number: 8680-P

  5. Szablowski JO, Shapiro MG, Methods And Systems For Noninvasive Control Of Brain Cells And Related Vectors And Compositions, Serial Number: 16/213,991, Filed: 12/7/2018, CIT File Number: 7921

  6. Lu G, Farhadi A, Szablowski JO, Shapiro MG, Gas Filled Structures and related compositions, methods and systems for magnetic resonance imaging, CIT File No.: CIT-7580-P, Provisional filed: 7/28/2016, Patent application filed: 7/28/2017

  7. Szablowski JO, User-adjustable knee orthosis for patellar instability and related disorders, CIT File No.: CIT 12-216, Provisional Filed: 8/7/2012

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