Publications
1. Huang Z, Mitrofan A, Nouraein S, Horak C, Seo JP, Harb M, Jin R, Szablowski JO*. Engineering Regionally-Activated Drugs for Neuroscience. bioRxiv. 2023:2023-10.
2. Seo JP, Trippett JS, Huang Z, Wang R, Lee S, Szablowski JO*, Acoustically-Targeted Measurement of Transgene Expression in the Brain, bioRxiv 2023.05.23.541868; doi: https://doi.org/10.1101/2023.05.23.541868
3. Nouraein S, Lee S, Saenz VA, Del Mundo HC, Yiu J, Szablowski JO*, Acoustically Targeted Noninvasive Gene Therapy in Large Brain Regions, bioRxiv 2023.01.19.524626, https://www.nature.com/articles/s41434-023-00421-1, in press, Gene Therapy
4. Lee S, Nouraein S, Kwon JJ, Huang Z, Szablowski JO, Engineered Serum Markers for Noninvasive Monitoring of Gene Expression in the Brain, bioRxiv 2022.07.17.500352; doi: https://doi.org/10.1101/2022.07.17.500352accepted in principle
5. Chen, M., Kim, B., Ruocco, M.1, Fleury, S., Deng, S., Nouraein, S. Lee, S., Butler, S., Szablowski, J.O., Suh, J., Veiseh, O. Immune profiling of adeno-associated virus response identifies B cell-specific targets that enable vector re-administration in mice. Gene Ther 30, 429–442 (2023). https://doi.org/10.1038/s41434-022-00371-0
6. Xia B*, Sebesta C*, Lee S*, Nair V, Zhao X, Coffler S, Robinson JT#, Szablowski JO#, Biohybrid approaches to interface with the nervous system: the best of both worlds, Current Opinion in Biotechnology, 72 (86-94), (2021)
(# corresponding)
7. Li H, Heath JE, Trippett JS, Shapiro MG#, Szablowski JO#, Engineering viral vectors for acoustically targeted gene delivery. bioRxiv 2021.07.26.453904; doi: https://doi.org/10.1101/2021.07.26.453904
(#corresponding)
8. Szablowski JO#, Harb M, Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation, J Vis Exp . 2020 Dec 22;(166). doi: 10.3791/61352.
(# corresponding)
9. Szablowski JO*, Bar-Zion A*, Shapiro MG, Achieving spatial and molecular specificity with ultrasound-targeted biomolecular therapeutics, Accounts of chemical research 52.9 (2019): 2427-2434.
* co-first
10. Szablowski JO, Lue B, Lee-Gosselin A, Malounda A, Shapiro MG, Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits, Nature Biomedical Engineering, (2), 475–484 (2018);
11. Maresca, D, Lakshmanan A, Abedi M, Bar-Zion A, Farhadi A, Lu GJ, Szablowski JO, Wu D, Yoo S, and Shapiro MG, Biomolecular Ultrasound and Sonogenetics. Annual review of chemical and biomolecular engineering, 9:229-252 (2018)
12. Lu, G. J., Farhadi, A., Szablowski, J. O., Lee-Gosselin, A., Barnes, S. R., Lakshmanan, A., ... & Shapiro, M. G. Acoustically modulated magnetic resonance imaging of gas-filled protein nanostructures. Nature Materials 17, 456–463 (2018)
13. Piraner DI, Farhadi A, Davis HC, Wu D, Maresca D, Szablowski JO, Shapiro MG, Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function, Biochemistry 56 (39), 5202-5209 (2018)
14. Mysore VS, Szablowski JO, Dervan PB, Frost PJ, A DNA-binding molecule targeting the adaptive hypoxic response in multiple myeloma has potent in vivo and in vitro anti-tumor effects, Molecular Cancer Research (2016), Mol Cancer Res Published OnlineFirst January 22, 2016
Featured in highlights: http://mcr.aacrjournals.org/content/14/3/239.full.pdf+html
15. Szablowski, JO.; Raskatov JA., Dervan, PB. "An HRE-binding Py-Im polyamide attenuates tumor growth and inhibits angiogenesis in vivo."; Molecular Cancer Therapeutics (2015), Mol Cancer Ther molcanther.0719.2015; Published OnlineFirst December 30, 2015
Featured in highlights: http://mct.aacrjournals.org/content/15/4/531.full.pdf+html
16. Raskatov JA.; Szablowski, JO.; Dervan, PB.; "Tumor Xenograft Uptake of a Py Im Polyamide Varies as a Function of Cell Line Grafted: a C-14 Study", Journal of Medicinal Chemistry 57 (20), 8471-8476 (2014)
17. Yang, F; Nickols, N; Li, Benjamin; Szablowski, JO; Hamilton, S; Meier, J; Wang, C; Dervan, PB, Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit, Journal of Medicinal Chemistry 56 (18), 7449-7457 (2013)
18. Nickols NG*,Szablowski JO*, Hargrove AE, Li BC, Raskatov JA, Activity of a Py-Im Polyamide Targeted to the Estrogen Response Element, Molecular Cancer Therapeutics, 12:675–84 (2013)
selected as a 'American Association for Cancer Research (AACR) hot topic 2013'.
* co-first
19. Cristina Vilanova, Ángeles Hueso, Carles Palanca, Guillem Marco,Miguel Pitarch, Eduardo Otero, Juny Crespo, Jerzy Szablowski, Sara Rivera,Laura Domínguez-Escribà, Emilio Navarro, Arnau Montagud, Pedro Fernández de Córdoba, Asier González, Joaquín Ariño,Andrés Moya, Javier Urchueguía & Manuel Porcar, "Aequorin-expressing yeast emits light under electric control" , J Biotechnol. 152(3):93-5. (2011)
20. Shapiro MG*, Westmeyer GG*, Romero P, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, & Jasanoff AP, Directed evolution of an MRI contrast agent for noninvasive imaging of dopamine. Nature Biotechnology 28, 264–270 (2010)
* co-first
21. Shapiro MG, Szablowski JO, Langer R, Jasanoff AP, Protein nanoparticles engineered to sense kinase activity in MRI, Journal of the American Chemical Society 2009 131 (7), 2484-2486
Patents
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Szablowski JO, Li H, Heath JE, Shapiro MG, Viral Vectors Engineered for Enhanced Ultrasound-Mediated Delivery to the Brain CIT File No.: CIT-8680-P, Filed: 7/23/2021
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Szablowski JO, Shapiro MG, California Institute of Technology, 2019. Methods and systems for noninvasive control of brain cells and related vectors and compositions. U.S. Patent Application 16/213,991.
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Lu G, Farhadi A, Szablowski JO, Shapiro MG, Shapiro,Gas-filled structures and related compositions, methods and systems for magnetic resonance imaging., U.S. Patent Application 15/663,600.
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Szablowski JO, User-adjustable knee orthosis for patellar instability and related disorders, CIT File 12-216, Provisional Filed: 8/7/2012