Gene therapy and noninvasive gene delivery to the brain

2017 - current, currently recruiting at all levels

We are currently working on improving noninvasive gene delivery to the brain through focused-ultrasound BBB opening (FUS-BBBO). Current work will improve cost, safety, and transduction efficiency of the technique. Our work also includes viral vector engineering. For an example application, see ATAC page.

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Image: Noninvasive gene delivery of an inhibitory DREADD (red). The immunostained red area is a mouse dorsal hippocampus showing pronounced expression of an inhibitory DREADD.

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These projects are supported by The G. Harold and Leila Y. Mathers Foundation and John S. Dunn Foundation.