Laboratory for Noninvasive Neuroengineering
We are developing technologies for noninvasive control and monitoring of the brain. In our work, we combine synthetic biology, molecular engineering, and strategies for enhanced gene and drug delivery into the central nervous system. Our goals are to understand neural circuit function and treat brain disorders with fewer side effects.
Keywords: gene delivery, protein engineering, neuromodulation, viral vector engineering, ultrasound
For examples, see our current research.
New paper in Nature Biotechnology introducing the synthetic serum marker paradigm. Congrats to the team! See: Engineered serum markers for non-invasive monitoring of gene expression in the brain
New preprint: Congrats to Dr. Zhimin Huang on developing Regionally-Activated Interstitial Drugs, or RAID!
New grant: Dr. Szablowski receives the NIH Director's New Innovator Award (DP2). We will use it to develop tools for monitoring gene expression in the brain with blood sampling.
New paper: Congrats to Shirin Nouraein et al. on a new paper in Gene Therapy, Acoustically targeted noninvasive gene therapy in large brain volumes.
Interview with Dr. Szablowski on our approach to accelerate drug discovery and therapy development out in Popular Mechanics.
Student award: Congrats to Sangsin Lee for receiving the Trainee Highlight Award from the NIH BRAIN initiative!
Student awards: Congrats to Andrei Mitrofan for receiving multiple awards at graduation, including Outstanding Senior in Bioengineering Award, James S. Waters Creativity Award, and Excellence in Capstone Engineering Award.
Student award: Congrats to Ryan Wang for becoming a Goldwater Scholar!
Student award: Congrats to Ryan Wang for receiving the Sigma Xi Society Grant in Aid of Research!
New preprint: Congrats Shirin Nouraein et al. on showing that naturally-occurring AAVs can be safely and noninvasively delivered to large swathes of the brain to enable 60% transduction efficiency and genome editing. See: Acoustically Targeted Noninvasive Gene Therapy in Large Brain Regions
New paper: Congrats to Sangsin Lee and Shirin Nouraein on a new accepted paper Targeted immunosuppression enhances repeated gene delivery in Gene Therapy.
New Grant: We've received an R21 from NIH to work on the noninvasive molecule delivery to the eye. The work will be done in collaboration with Dr. Ben Frankfort at Baylor College of Medicine.
Dr. Szablowski receives NIBIB Trailblazer Award to support the work on noninvasive monitoring of gene expression in the brain.
Joon Pyung Seo receives APP Travel Award. Congrats!
New preprint: Congrats Sangsin Lee et al. on a developing a novel class of gene expression reporters - Released Markers of Activity or RMA, see the preprint: Engineered Serum Markers for Noninvasive Monitoring of Gene Expression in the Brain
Congrats to Andrei Mitrofan on receiving an REA International service award!
New preprint: Congrats to Sangsin Lee and Shirin Nouraein on a newly submitted manuscript titled: Targeted immunosuppression enhances repeated gene delivery
Dr. Szablowski selected as a 2021 Packard Fellow in Science and Engineering.
New paper: Congrats to Boao, Sin, and our collaborators in Robinson lab on a newly accepted review paper in Current Opinion in Biotechnology titled: Biohybrid approaches to interface with the nervous system: the best of both worlds.
New Grant: The Michael J. Fox Foundation for Parkinson's Research will be supporting our work on identifying new markers for early detection and staging of Parkinson's Disease in collaboration with Drs. Sameer Sheth and Nora Vannegas-Arroyave.
New preprint: Congratulations to Jake Trippett and our team of collaborators at Caltech for developing a viral vector engineered for acoustically-targeted gene delivery.
New Grant: G. Harold and Leila Y. Mathers Charitable Foundation will support our work on Acoustically Targeted Chemogenetics (ATAC).
Congratulations to Manwal Harb, and a lab alum Tsvetelina Baryakova for their NSF GRFP fellowships and to Joycelyn Yiu for the NSF GRFP honorable mention!
Invited Talk at Columbia University
Invited talk at Mount Sinai School of Medicine, Neuroscience Center, as a part of #MSNSeminars
ATAC in the news.
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6100 Main St., Houston, TX 77005-1892
Mailing Address: P.O. Box 1892 Houston, TX 77251-1892